Autofluorescence of low-density lipoproteins modified as a result of autooxidation

Autooxidation of low-density lipoproteins during incubation at 37 degrees C was accompanied by accumulation of LPO products, decrease in UV autofluorescence (FUV), and increase in autofluorescence in the visible band (FVIS). The degree of low-density lipoprotein modification was estimated by calcula...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-10, Vol.142 (4), p.433-436
Main Authors: Aidyraliev, R K, Azizova, O A, Vakhrusheva, T V, Lopukhin, Yu M, Mirrakhimov, M M
Format: Article
Language:English
Subjects:
Anthracenes
Edetic Acid - pharmacology
Fluorescence
Humans
Kinetics
Lipid Peroxidation
Lipoproteins, LDL - blood
Lipoproteins, LDL - chemistry
Lipoproteins, LDL - drug effects
Oxidation-Reduction
Reference Values
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Summary:Autooxidation of low-density lipoproteins during incubation at 37 degrees C was accompanied by accumulation of LPO products, decrease in UV autofluorescence (FUV), and increase in autofluorescence in the visible band (FVIS). The degree of low-density lipoprotein modification was estimated by calculating the FVIS/FUV ratio. A positive correlation was revealed between this ratio and concentration of thiobarbituric acid-reactive LPO products (r=0.76, p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0385-8