An ovine chitinase-like molecule, chitinase-3 like-1 (YKL-40), is upregulated in the abomasum in response to challenge with the gastrointestinal nematode, Teladorsagia circumcincta

Mammalian chitinases and chitinase-like proteins are a group of molecules known to be upregulated and secreted in Th2-induced inflammatory responses, such as asthma, allergy and nematode infection. As part of an investigation of potential components of the innate immune response to Teladorsagia circ...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 2007-11, Vol.120 (1), p.55-60
Main Authors: Knight, P.A., Pate, J., Smith, W.D., Miller, H.R.P.
Format: Article
Language:English
Subjects:
Abomasum - immunology
Animals
Chitinase
Chitinase-like protein
Chitinases - metabolism
Nematoda
Nematode
Ovis aries
Reverse Transcriptase Polymerase Chain Reaction - veterinary
Sheep
Sheep Diseases - immunology
Sheep Diseases - metabolism
Teladorsagia
Trichostrongyloidea - physiology
Trichostrongyloidiasis - immunology
Trichostrongyloidiasis - metabolism
Trichostrongyloidiasis - veterinary
Up-Regulation - immunology
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Summary:Mammalian chitinases and chitinase-like proteins are a group of molecules known to be upregulated and secreted in Th2-induced inflammatory responses, such as asthma, allergy and nematode infection. As part of an investigation of potential components of the innate immune response to Teladorsagia circumcincta, a gastrointestinal nematode that colonises the abomasum in sheep, we carried out RT-PCR analysis of two members of the mammalian chitinase family of molecules, acidic chitinase (ChiA) and chitinase-3 like 1 (Chi3L1) using primers to homologous bovine/human sequences. Both sets of primers detected transcripts in the abomasum which were confirmed to be ovine ChiA and Chi3L1 by sequence analysis. Chi3L1 transcripts were found to be significantly upregulated in both the abomasum and gastric lymph nodes in response to T. circumcincta challenge of previously infected animals.
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2007.07.005