Using Magnetic Force to Enhance Immune Response to DNA Vaccine

The improvement of the gene distribution within skeletal muscle to enhance the immunogenicity of DNA vaccines is reported. Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2007-10, Vol.3 (10), p.1707-1713
Main Authors: Zhou, Xian-Feng, Liu, Bin, Yu, Xiang-Hui, Zha, Xiao, Zhang, Xi-Zhen, Wang, Xue-Yun, Jin, Ying-Hua, Wu, Yong-Ge, Jiang, Chun-Lai, Chen, Yue, Chen, Yan, Shan, Ya-Ming, Liu, Jun-Qiu, Kong, Wei, Shen, Jia-Cong
Format: Article
Language:English
Subjects:
Animals
Cercopithecus aethiops
COS Cells
DNA
drug delivery
immunogenicity
magnetic nanoparticles
Magnetics
Mice
Mice, Inbred BALB C
Microscopy, Electron, Transmission
Muscle, Skeletal - cytology
Nanoparticles - chemistry
Transfection
vaccines
Vaccines, DNA - immunology
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Summary:The improvement of the gene distribution within skeletal muscle to enhance the immunogenicity of DNA vaccines is reported. Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at low vector doses, is utilized. After immunization, the magnetic DNA vector induces significantly enhanced serum antibody responses 2–3 orders of magnitude greater than naked DNA.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.200700151