Heart sensitivity to electrolyte composition of perfusion solution of rats after severe brain injury

The in vitro model of isovolumic beating heart revealed enhanced sensitivity of the hearts from rats survived severe brain injury to concentration of Ca(2+), Na(+), and H(+) ions in the perfusion solution. Inhibition of myocardial contractile function after trauma was accompanied by destruction sign...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-06, Vol.141 (6), p.691-694
Main Authors: Rusakov, V V, Dolgikh, V T
Format: Article
Language:English
Subjects:
Animals
Blood Glucose
Blood Pressure - drug effects
Brain Injuries - physiopathology
Calcium - pharmacology
Electrolytes - pharmacology
Hydrogen-Ion Concentration
Lactic Acid - blood
Male
Myocardial Contraction - drug effects
Myocardial Contraction - physiology
Perfusion
Rats
Rats, Wistar
Sodium - pharmacology
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Summary:The in vitro model of isovolumic beating heart revealed enhanced sensitivity of the hearts from rats survived severe brain injury to concentration of Ca(2+), Na(+), and H(+) ions in the perfusion solution. Inhibition of myocardial contractile function after trauma was accompanied by destruction signs in cardiomyocyte sarcolemma and mitochondrial dysfunction.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0254-5