Morphofunctional study of the therapeutic effect of autologous mesenchymal stem cells in experimental diffuse brain injury in rats

Effects of systemic transplantation of mesenchymal stem cells obtained by culturing of autologous bone marrow on proliferative activity of cells and functional morphology of neurons after diffuse brain injury were studied in Wistar rats. Comparative analysis of the results indicated that systemic in...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-07, Vol.142 (1), p.140-147
Main Authors: Tsyb, A F, Roshal', L M, Yuzhakov, V V, Konoplyannikov, A G, Sushkevich, G N, Bandurko, L N, Ingel', I E, Semenova, Zh B, Konoplyannikova, O A, Lepekhina, L A, Kal'sina, S Sh, Verkhovskii, Yu G, Shevchuk, A S, Semenkova, I V
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Autografts
Bone marrow transplantation
Brain Injuries - pathology
Brain Injuries - therapy
Brain injury
Cell Proliferation
Comparative analysis
Cytology
Functional morphology
Histological Techniques
Injection
Injections, Intravenous
Intravenous administration
Ischemia
Male
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal stem cells
Neovascularization, Physiologic - physiology
Neurons - cytology
Neuroprotection
Rats
Rats, Wistar
Regeneration
Rodents
Stem cell transplantation
Stem cells
Syngeneic grafts
Transplantation, Isogeneic - methods
Traumatic brain injury
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Summary:Effects of systemic transplantation of mesenchymal stem cells obtained by culturing of autologous bone marrow on proliferative activity of cells and functional morphology of neurons after diffuse brain injury were studied in Wistar rats. Comparative analysis of the results indicated that systemic injection of mesenchymal stem cells in a syngeneic organism produced proliferotropic, angiogenic, and, presumably, neurotrophic effects. The therapeutic effect visually manifested on day 2 after intravenous injection of mesenchymal stem cells during the early period of reparative regeneration of ischemic cell and tissue structures of the brain. The neuroprotective effect of mesenchymal stem cells was more pronounced against the background of basic therapy.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0313-y