Ubiquitination, phosphorylation, and acetylation-triple threat in muscle wasting

Loss of muscle mass is commonly seen in patients with critical illness and is associated with increased expression of multiple genes controlling protein breakdown. Transcription factors that are activated during muscle wasting include NF‐kB and members of the FOXO and C/EBP transcription factor fami...

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Bibliographic Details
Published in:Journal of cellular physiology 2007-12, Vol.213 (3), p.679-689
Main Author: Hasselgren, Per-Olof
Format: Article
Language:English
Subjects:
Acetylation
Animals
Gene Expression Regulation
Humans
Models, Biological
Muscular Atrophy - metabolism
Phosphorylation
Protein Processing, Post-Translational
Transcription Factors - genetics
Transcription Factors - metabolism
Ubiquitination
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Summary:Loss of muscle mass is commonly seen in patients with critical illness and is associated with increased expression of multiple genes controlling protein breakdown. Transcription factors that are activated during muscle wasting include NF‐kB and members of the FOXO and C/EBP transcription factor families. The activity of these transcription factors is regulated by multiple posttranslational modifications, including ubiquitination, phosphorylation, and acetylation, providing for a complex and integrated network of regulatory mechanisms in muscle wasting. Targeting posttranslational modifications of transcription factors may prove important in the prevention and treatment of the debilitating consequences of muscle wasting. J. Cell. Physiol. 213:679–689. © 2007 Wiley‐Liss, Inc.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.21190