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Expression of c-kit in North African nasopharyngeal carcinomas: correlation with age and LMP1
To determine the level and prognostic significance of c-kit expression in the two age groups of North African nasopharyngeal carcinomas. A retrospective study of 99 NPC specimens from Tunisian patients was investigated by immunohistochemistry. Immunohistochemical data were correlated with Epstein-Ba...
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Published in: | Cancer radiothérapie 2007-09, Vol.11 (5), p.247-251 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | fre |
Subjects: | |
Online Access: | Get full text |
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Summary: | To determine the level and prognostic significance of c-kit expression in the two age groups of North African nasopharyngeal carcinomas.
A retrospective study of 99 NPC specimens from Tunisian patients was investigated by immunohistochemistry. Immunohistochemical data were correlated with Epstein-Barr virus LMP1 expression and pathological, clinical and survival parameters.
c-kit was detected in 79% of the cases for patients under 30 years of age (juvenile form) but in only 56% of specimens in patients over 30 years (P=0.039) and was significantly over-expressed for patients with lymph node involvement (P=0.015). LMP1 score was 5.78 (+/-1.84) for c-kit negative tumors compared to 8,23 (+/-2.39) for c-kit positive tumors (P=0.002). Multivariate analysis including age, lymph nodes involvement and LMP1 expression as co-variables, showed that only age (P=0.027) and LMP1 expression (P=0.005) were significantly correlated to the c-kit expression.
c-kit is highly expressed in the juvenile form of North African nasopharyngeal carcinomas. There is a significant association between LMP1 and c-kit expression. The contrasted levels of C-kit expression in the two age groups strengthen the hypothesis that these clinical forms result from distinct oncogenic mechanisms. |
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ISSN: | 1278-3218 |
DOI: | 10.1016/j.canrad.2007.06.007 |