Association of RNASEL Variants with Prostate Cancer Risk in Hispanic Caucasians and African Americans

• Published in: Clinical cancer research 2007-10, Vol.13 (19), p.5959-5964
• Main Authors: SHOOK, Stacie J, BEUTEN, Joke, TORKKO, Kathleen C, JOHNSON-PAIS, Teresa L, TROYER, Dean A, THOMPSON, Lan M, LEACH, Robin J
• Format: Article
• Language: English
• Subjects: African Americans; African Continental Ancestry Group; Aged; Antineoplastic agents; Biological and medical sciences; Endoribonucleases - genetics; Endoribonucleases - physiology; European Continental Ancestry Group; Gene Expression Regulation, Neoplastic; Genetic Linkage; Genetic Predisposition to Disease; Genetic Variation; Gynecology. Andrology. Obstetrics; Hispanic Americans; Humans; Male; Male genital diseases; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Pharmacology. Drug treatments; prostate cancer risk; Prostatic Neoplasms - ethnology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Risk; RNASEL; single nucleotide polymorphism; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland
• ISSN: 1078-0432; 1557-3265
• DOI: 10.1158/1078-0432.CCR-07-0702

Purpose: The RNASEL gene at 1q25 has been identified as a hereditary prostate cancer susceptibility gene, but to date, no study has investigated the role of RNASEL variants in Hispanic Caucasian men with prostate cancer. Experimental Design: Two RNASEL common variants, located at amino acids 462 and 541, were genotyped in non-Hispanic Caucasian, Hispanic Caucasian, and African American prostate cancer cases and controls. Results: The RNASEL 462 AA genotype was found to increase prostate cancer risk over 4-fold in Hispanic Caucasians [odds ratio (OR), 4.43; 95% confidence interval (95% CI), 1.68-11.68; P = 0.003] and over 10-fold in African Americans (OR, 10.41; 95% CI, 2.62-41.40; P = 0.001) when compared with the GG genotype. Analysis of the RNASEL 541 variant showed that Hispanic Caucasian patients with the GG genotype had a statistically significant increase in their risk for developing prostate cancer when compared with the TT and GT genotypes (OR, 1.91; 95% CI, 1.16-3.14; P = 0.01). A common G-T haplotype for the combination of the RNASEL 462 and 541 variants was found to occur more frequently in controls compared with cases in African Americans ( P = 0.04) but not in non-Hispanic Caucasians or Hispanic Caucasians. Conclusions: This is the first study that investigates the association of prostate cancer risk with RNASEL variants in Hispanic men. Our data support the role of RNASEL as a predisposition gene for prostate cancer and showed a significant association between the RNASEL 462 variant and prostate cancer risk in African Americans and Hispanic Caucasians.