The integrin-growth factor receptor duet

Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In...

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Bibliographic Details
Published in:Journal of cellular physiology 2007-12, Vol.213 (3), p.649-653
Main Authors: Alam, Naved, Goel, Hira Lal, Zarif, Matthew J., Butterfield, Julie E., Perkins, Hillary M., Sansoucy, Brian G., Sawyer, Thomas K., Languino, Lucia R.
Format: Article
Language:English
Subjects:
Animals
Forecasting
Humans
Integrins - metabolism
Ligands
Models, Biological
Receptors, Growth Factor - metabolism
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Summary:Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we review the role of integrins as molecular switches that modulate GFR activation and specificity. We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine‐tuned. J. Cell. Physiol. 213:649–653. © 2007 Wiley‐Liss, Inc.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.21278