MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo

In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ‐16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA‐4AmC− in mouse kidney. The performance of the technique...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2007-10, Vol.58 (4), p.650-655
Main Authors: Vinogradov, Elena, He, Huamei, Lubag, Angelo, Balschi, James A., Sherry, A. Dean, Lenkinski, Robert E.
Format: Article
Language:English
Subjects:
Animals
contrast
exchange
Female
Kidney - anatomy & histology
low B1 WALTZ-16
Magnetic Resonance Imaging
Male
Mice
OPARACHEE
Organometallic Compounds
PARACEST
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Summary:In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ‐16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA‐4AmC− in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal‐to‐noise ratio (SNR) levels. The lowest injected concentration of TmDOTA‐4AmC−, 200 μL of a 2‐mM stock solution (corresponds to ∼0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low‐amplitude RF trains can detect paramagnetic exchanging agents in vivo. Magn Reson Med 58:650–655, 2007. © 2007 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.21393