Association of body mass index and Trp64Arg polymorphism of the beta3-adrenoreceptor gene and leptin level in Tehran Lipid and Glucose Study

In this study the association between beta3-adrenoceptor gene polymorphism and serum concentration of leptin with body mass index (BMI) is investigated. Using subjects in the Tehran Lipid and Glucose Study, genotyping of the Trp64Arg polymorphism of the beta3-adrenoreceptor gene was performed using...

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Bibliographic Details
Published in:British journal of biomedical science 2007, Vol.64 (3), p.117-120
Main Authors: Eshraghi, P, Hedayati, M, Daneshpour, M S, Mirmiran, P, Azizi, F
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Blood Glucose - analysis
Body Mass Index
Female
Humans
Iran - epidemiology
Leptin - metabolism
Lipids - blood
Male
Middle Aged
Obesity - blood
Obesity - genetics
Polymorphism, Genetic - genetics
Receptors, Adrenergic, beta-3 - genetics
Receptors, Leptin - metabolism
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Summary:In this study the association between beta3-adrenoceptor gene polymorphism and serum concentration of leptin with body mass index (BMI) is investigated. Using subjects in the Tehran Lipid and Glucose Study, genotyping of the Trp64Arg polymorphism of the beta3-adrenoreceptor gene was performed using a restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique was used and the association with obesity was investigated. At total of 197 men and 204 women were divided into four groups (BMI
ISSN:0967-4845