Suppression of Experimental Autoimmune Myasthenia Gravis by Intravenous Immunoglobulin and Isolation of a Disease-Specific IgG Fraction

:  Intravenous immunoglobulin (IVIG) administration has been beneficially used for the treatment of a variety of autoimmune diseases including myasthenia gravis (MG). We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompan...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2007-09, Vol.1110 (1), p.550-558
Main Authors: FUCHS, SARA, FEFERMAN, TALI, ZHU, KAI-YUN, MEIDLER, ROBERTO, MARGALIT, RAANAN, WANG, NINGSHAN, LAUB, ORGAD, SOUROUJON, MIRIAM C.
Format: Article
Language:English
Subjects:
Animals
experimental autoimmune myasthenia gravis (EAMG)
Humans
Immunoglobulin G - immunology
Immunoglobulin G - isolation & purification
Immunoglobulin G - therapeutic use
Immunoglobulins, Intravenous - immunology
Immunoglobulins, Intravenous - therapeutic use
Immunotherapy
intravenous immunoglobulin
IVIG
MG
myasthenia gravis
Myasthenia Gravis, Autoimmune, Experimental - immunology
Myasthenia Gravis, Autoimmune, Experimental - pathology
Myasthenia Gravis, Autoimmune, Experimental - therapy
Rats
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Summary::  Intravenous immunoglobulin (IVIG) administration has been beneficially used for the treatment of a variety of autoimmune diseases including myasthenia gravis (MG). We have demonstrated that IVIG administration in experimental autoimmune MG (EAMG) results in suppression of disease that is accompanied by decreased Th1 cell and B cell proliferation. Chromatography of pooled human immunoglobulins (IVIGs) on immobilized IgG, isolated from rats with EAMG, results in a complete depletion of the suppressive activity of the IVIG. Moreover, the eluate from this EAMG‐specific antibody column retains the immunosuppressive activity of IVIG. This study supports the notion that the therapeutic effect of IVIGs is mediated by an antigen‐specific anti‐immunoglobulin (anti‐idiotypic) activity that is essential for its suppressive activity.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1423.059