Understanding the minimum clinically important difference: a review of concepts and methods

• Published in: The spine journal 2007-09, Vol.7 (5), p.541-546
• Main Authors: Copay, Anne G., PhD, Subach, Brian R., MD, Glassman, Steven D., MD, Polly, David W., MD, Schuler, Thomas C., MD
• Format: Article
• Language: English
• Subjects: Bias; Clinical Trials as Topic - methods; Data Interpretation, Statistical; Disability; Functional assessment; Humans; Metrics; Minimum clinically important difference; Orthopedics; Outcomes measures; Sensitivity and Specificity; Spinal Diseases - therapy; Treatment Outcome
• ISSN: 1529-9430; 1878-1632
• DOI: 10.1016/j.spinee.2007.01.008

Abstract Background context The effectiveness of spinal surgery as a treatment option is currently evaluated through the assessment of patient-reported outcomes (PROs). The minimum clinically important difference (MCID) represents the smallest improvement considered worthwhile by a patient. The concept of an MCID is offered as the new standard for determining effectiveness of a given treatment and describing patient satisfaction in reference to that treatment. Purpose Our goal is to review the various definitions of MCID and the methods available to determine MCID. Study design The primary means of determining the MCID for a specific treatment are divided into anchor-based and distribution-based methods. Each method is further subdivided and examined in detail. Methods The overall limitations of the MCID concept are first identified. The basic assumptions, statistical biases, and shortcomings of each method are examined in detail. Results Each method of determining the MCID has specific shortcomings. Three general limitations in the accurate determination of an MCID have been identified: the multiplicity of MCID determinations, the loss of the patient's perspective, and the relationship between pretreatment baseline and posttreatment change scores. Conclusions An ideal means of determining the MCID for a given intervention is yet to be determined. It is possible to develop a useful method provided that the assumptions and methodology are initially declared. Our efforts toward the establishment of a MCID will rely on the establishment of specific external criteria based on the symptoms of the patient and treatment intervention being evaluated.