Copper(II) Complexes of Salicylaldehyde Hydrazones: Synthesis, Structure, and DNA Interaction

Three hydrazone ligands, H2L1–H2L3, made from salicylaldehyde and ibuprofen‐ or naproxen‐derived hydrazides, were prepared and transformed into the corresponding copper(II) complexes [CuIIL1]⋅H2O, [CuIIL2], and [(CuII)2(L3)2]⋅H2O⋅DMF (Scheme). The X‐ray crystal structure of the last‐mentioned comple...

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Bibliographic Details
Published in:Chemistry & biodiversity 2007-09, Vol.4 (9), p.2198-2209
Main Authors: Wu, La-Mei, Teng, Han-Bing, Ke, Xian-Bing, Xu, Wen-Jin, Su, Jiang-Tao, Liang, Shu-Cai, Hu, Xian-Ming
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Copper - chemistry
Copper complexes
Crystallography, X-Ray
DNA
DNA - chemistry
Hydrazones
Hydrazones - chemical synthesis
Hydrazones - chemistry
Intercalating Agents - chemical synthesis
Intercalating Agents - chemistry
Molecular Structure
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Tetradentate ligands
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Summary:Three hydrazone ligands, H2L1–H2L3, made from salicylaldehyde and ibuprofen‐ or naproxen‐derived hydrazides, were prepared and transformed into the corresponding copper(II) complexes [CuIIL1]⋅H2O, [CuIIL2], and [(CuII)2(L3)2]⋅H2O⋅DMF (Scheme). The X‐ray crystal structure of the last‐mentioned complex was solved (Fig. 1), showing a square‐planar complexation geometry, and the single units were found to form a one‐dimensional chain structure (Fig. 2). The interactions of these complexes with CT‐DNA were studied by different techniques, indicating that they all bind to DNA by classical and/or non‐classical intercalation modes.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.200790177