Type IIB von Willebrand Disease: Role of Qualitative Defects in Atherosclerosis and Endothelial Dysfunction

Objective. To verify whether a hereditary bleeding tendency, such as von Willebrand disease (vWD) type IIB, protects against the onset of atherosclerosis. Participants and Methods. Twenty-four patients with vWD type IIB and 24 healthy controls, matched for common atherosclerotic risk factors. All pa...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2007-10, Vol.13 (4), p.384-390
Main Authors: Bilora, Franca, Zanon, Ezio, Casonato, Alessandra, Bertomoro, Antonella, Petrobelli, Francesco, Cavraro, Monica, Campagnolo, Enrico, Girolami, Antonio
Format: Article
Language:English
Subjects:
Adult
Aged
Arteries - diagnostic imaging
Atherosclerosis
Atherosclerosis - complications
Atherosclerosis - pathology
Atherosclerosis - physiopathology
Atherosclerosis - prevention & control
Brachial Artery - diagnostic imaging
Brachial Artery - physiopathology
Case-Control Studies
Endothelium, Vascular - pathology
Endothelium, Vascular - physiopathology
Female
Health risk assessment
Humans
Male
Middle Aged
Ultrasonography
Veins & arteries
von Willebrand Diseases - complications
von Willebrand Diseases - pathology
von Willebrand Diseases - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. To verify whether a hereditary bleeding tendency, such as von Willebrand disease (vWD) type IIB, protects against the onset of atherosclerosis. Participants and Methods. Twenty-four patients with vWD type IIB and 24 healthy controls, matched for common atherosclerotic risk factors. All patients were evaluated by color Doppler ultrasound of the common carotid, carotid bifurcation, common femoral artery, brachial artery, and abdominal aorta, investigating intima-media thickness (IMT) and presence of plaques in each arterial district. Flow mediated dilation (FMD) of the brachial artery was used to test endothelial function. Results. vWD type IIB patients presented no significant difference in IMT in any arterial district. FMD showed no differences between the 2 groups. Conclusions. The quantitative clotting defect characteristic of vWD type IIB does not seem to protect against atherosclerosis.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029607303613