Review: Photopolymerizable and Degradable Biomaterials for Tissue Engineering Applications

Photopolymerizable and degradable biomaterials are finding widespread application in the field of tissue engineering for the engineering of tissues such as bone, cartilage, and liver. The spatial and temporal control afforded by photoinitiated polymerizations has allowed for the development of injec...

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Bibliographic Details
Published in:Tissue engineering 2007-10, Vol.13 (10), p.2369-2385
Main Authors: Ifkovits, Jamie L., Burdick, Jason A.
Format: Article
Language:English
Subjects:
Absorbable Implants
Biocompatible Materials - chemistry
Biodegradable materials
Biomedical materials
Cell Culture Techniques - methods
Light
Mechanical properties
Photochemistry - methods
Polymers
Polymers - chemistry
Polymers - radiation effects
Tissue engineering
Tissue Engineering - methods
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Summary:Photopolymerizable and degradable biomaterials are finding widespread application in the field of tissue engineering for the engineering of tissues such as bone, cartilage, and liver. The spatial and temporal control afforded by photoinitiated polymerizations has allowed for the development of injectable materials that can deliver cells and growth factors, as well as for the fabrication of scaffolding with complex structures. The materials developed for these applications range from entirely synthetic polymers (e.g., poly(ethylene glycol)) to purely natural polymers (e.g., hyaluronic acid) that are modified with photoreactive groups, with degradation based on the hydrolytic or enzymatic degradation of bonds in the polymer backbone or crosslinks. The degradation behavior also ranges from purely bulk to entirely surface degrading, based on the nature of the backbone chemistry and type of degradable units. The mechanical properties of these polymers are primarily based on factors such as the network crosslinking density and polymer concentration. As we better understand biological features necessary to control cellular behavior, smarter materials are being developed that can incorporate and mimic many of these factors.
ISSN:1076-3279
1557-8690
DOI:10.1089/ten.2007.0093