The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility

Summary The present study was designed to investigate an association of common -588C/T and -23G/T polymorphisms within glutamate cysteine ligase modifier subunit gene with susceptibility to bronchial asthma. A total of 435 ethnically Russian subjects were recruited in this study, including 221 patie...

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Bibliographic Details
Published in:Respiratory medicine 2007-11, Vol.101 (11), p.2422-2424
Main Authors: Polonikov, A.V, Ivanov, V.P, Solodilova, M.A, Khoroshaya, I.V, Kozhuhov, M.A, Panfilov, V.I
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Airway management
Antioxidant enzyme
Antioxidants
Asthma
Asthma - genetics
Case-Control Studies
Female
Free radicals
Gene expression
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Glutamate cysteine ligase
Glutamate-Cysteine Ligase - genetics
Glutathione - biosynthesis
Glutathione metabolism
Humans
Male
Middle Aged
Oxidative stress
Pathogenesis
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Pulmonary/Respiratory
Risk Factors
Single nucleotide polymorphism
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Summary:Summary The present study was designed to investigate an association of common -588C/T and -23G/T polymorphisms within glutamate cysteine ligase modifier subunit gene with susceptibility to bronchial asthma. A total of 435 ethnically Russian subjects were recruited in this study, including 221 patients with asthma and 214 sex and age matched healthy subjects. As previously reported, the -588C/T and -23G/T polymorphisms were completely linked. The -588TT/-23TT genotype was found to be associated with decreased risk of allergic asthma after adjustment for age, gender and smoking status using multivariate logistic regression analysis (OR=0.33 95% CI 0.15–0.70, p =0.036). However, the -588CT/-23GT genotype was associated with increased risk of non-allergic asthma (OR=2.03 95% CI 1.05–3.90, p =0.06). This is a first study reporting the association between genetic variations in the glutamate cysteine ligase gene and susceptibility to bronchial asthma.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2007.06.012