Cholinergic sensory inputs to command neurons in edible snail

We studied cholinergic component of visceral sensory input to defensive behavior command neurons in edible snail. Nicotinic receptor antagonist tubocurarine and muscarinic receptor antagonist atropine reversibly decreased the amplitude of the total excitatory postsynaptic potential induced by electr...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-09, Vol.142 (3), p.275-278
Main Authors: Palikhova, T A, Abramova, M S, Pivovarov, A S
Format: Article
Language:English
Subjects:
Animals
Atropine - pharmacology
Electric Stimulation
Helix (Snails) - drug effects
Helix (Snails) - physiology
Kinetics
Muscarinic Antagonists - pharmacology
Neurons - drug effects
Neurons - physiology
Nicotinic Antagonists - pharmacology
Patch-Clamp Techniques
Receptors, Muscarinic - metabolism
Receptors, Nicotinic - metabolism
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Tubocurarine - pharmacology
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Summary:We studied cholinergic component of visceral sensory input to defensive behavior command neurons in edible snail. Nicotinic receptor antagonist tubocurarine and muscarinic receptor antagonist atropine reversibly decreased the amplitude of the total excitatory postsynaptic potential induced by electrostimulation of the peripheral region in the mechanosensory receptor field of command neurons on the surface of internal organs. Our results indicate that acetylcholine is involved in sensory signal transduction from the visceral sac to command neurons of snail parietal ganglia. The subsynaptic membrane of visceral synaptic input contains nicotinic and muscarinic receptors.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0345-3