Modelling flow rate gradient elution in reversed-phase liquid chromatography

The fundamental equation of flow programming elution was tested in several different types of flow-rate gradients (step, linear, multilinear, parabolic and more combined gradients) implemented in the separation of two multicomponent mixtures of solutes. The retention prediction obtained for all solu...

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Published in:Analytica chimica acta 2006-07, Vol.573, p.305-310
Main Authors: Louisi, A. Pappa, Nikitas, P., Zitrou, A.
Format: Article
Language:English
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Flow rate gradient
Liquid chromatography
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description The fundamental equation of flow programming elution was tested in several different types of flow-rate gradients (step, linear, multilinear, parabolic and more combined gradients) implemented in the separation of two multicomponent mixtures of solutes. The retention prediction obtained for all solutes under all flow-programmed conditions was excellent. In addition, although flow programming appears quite limited in its ability to provide improved performance in liquid chromatography, there are specific flow-rate profiles which provide significant improvement in the rearrangement of the peaks within a chromatogram.
doi_str_mv 10.1016/j.aca.2006.03.038
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subjects Flow rate gradient
Liquid chromatography
title Modelling flow rate gradient elution in reversed-phase liquid chromatography
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