A mesoscopic stochastic mechanism of cytosolic calcium oscillations

Based on a model of intracellular calcium (Ca 2+) oscillation with self-modulation of inositol 1,4,5-trisphosphate signal, the mesoscopic stochastic differential equations for the intracellular Ca 2+ oscillations are theoretically derived by using the chemical Langevin equation method. The effects o...

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Bibliographic Details
Published in:Biophysical chemistry 2007, Vol.125 (1), p.201-212
Main Authors: Zhu, Chun-lian, Jia, Ya, Liu, Quan, Yang, Li-jian, Zhan, Xuan
Format: Article
Language:English
Subjects:
Calcium - metabolism
Calcium Signaling - physiology
Chemical Langevin equation
Cytosol - metabolism
Finite molecule number
Inositol 1,4,5-Trisphosphate - physiology
Intracellular calcium oscillations
Models, Biological
Oscillometry
Stochastic Processes
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Summary:Based on a model of intracellular calcium (Ca 2+) oscillation with self-modulation of inositol 1,4,5-trisphosphate signal, the mesoscopic stochastic differential equations for the intracellular Ca 2+ oscillations are theoretically derived by using the chemical Langevin equation method. The effects of the finite biochemical reaction molecule number on both simple and complex cytosolic Ca 2+ oscillations are numerically studied. In the case of simple intracellular Ca 2+ oscillation, it is found that, with the increase of molecule number, the coherence resonance or autonomous resonance phenomena can occur for some external stimulation parameter values. In the cases of complex cytosolic Ca 2+ oscillations, each extremum of concentration of cytosolic Ca 2+ oscillations corresponds to a peak in the histogram of Ca 2+ concentration, and the most probability appeared during the bursting plateau level for bursting, but at the largest minimum of Ca 2+ concentration for chaos. For quasi-periodicity, however, there are only two peaks in the histogram of Ca 2+ concentration, and the most probability is located at low concentration state.
ISSN:0301-4622
1873-4200
DOI:10.1016/j.bpc.2006.08.001