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A mesoscopic stochastic mechanism of cytosolic calcium oscillations
Based on a model of intracellular calcium (Ca 2+) oscillation with self-modulation of inositol 1,4,5-trisphosphate signal, the mesoscopic stochastic differential equations for the intracellular Ca 2+ oscillations are theoretically derived by using the chemical Langevin equation method. The effects o...
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| Published in: | Biophysical chemistry 2007, Vol.125 (1), p.201-212 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c382t-3a32ca7e29f8abf96a10a7bcb41477e66640bcc79b2ee969b27a36ea1b33d5b03 |
| container_end_page | 212 |
| container_issue | 1 |
| container_start_page | 201 |
| container_title | Biophysical chemistry |
| container_volume | 125 |
| creator | Zhu, Chun-lian Jia, Ya Liu, Quan Yang, Li-jian Zhan, Xuan |
| description | Based on a model of intracellular calcium (Ca
2+) oscillation with self-modulation of inositol 1,4,5-trisphosphate signal, the mesoscopic stochastic differential equations for the intracellular Ca
2+ oscillations are theoretically derived by using the chemical Langevin equation method. The effects of the finite biochemical reaction molecule number on both simple and complex cytosolic Ca
2+ oscillations are numerically studied. In the case of simple intracellular Ca
2+ oscillation, it is found that, with the increase of molecule number, the coherence resonance or autonomous resonance phenomena can occur for some external stimulation parameter values. In the cases of complex cytosolic Ca
2+ oscillations, each extremum of concentration of cytosolic Ca
2+ oscillations corresponds to a peak in the histogram of Ca
2+ concentration, and the most probability appeared during the bursting plateau level for bursting, but at the largest minimum of Ca
2+ concentration for chaos. For quasi-periodicity, however, there are only two peaks in the histogram of Ca
2+ concentration, and the most probability is located at low concentration state. |
| doi_str_mv | 10.1016/j.bpc.2006.08.001 |
| format | article |
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2+) oscillation with self-modulation of inositol 1,4,5-trisphosphate signal, the mesoscopic stochastic differential equations for the intracellular Ca
2+ oscillations are theoretically derived by using the chemical Langevin equation method. The effects of the finite biochemical reaction molecule number on both simple and complex cytosolic Ca
2+ oscillations are numerically studied. In the case of simple intracellular Ca
2+ oscillation, it is found that, with the increase of molecule number, the coherence resonance or autonomous resonance phenomena can occur for some external stimulation parameter values. In the cases of complex cytosolic Ca
2+ oscillations, each extremum of concentration of cytosolic Ca
2+ oscillations corresponds to a peak in the histogram of Ca
2+ concentration, and the most probability appeared during the bursting plateau level for bursting, but at the largest minimum of Ca
2+ concentration for chaos. For quasi-periodicity, however, there are only two peaks in the histogram of Ca
2+ concentration, and the most probability is located at low concentration state.</description><identifier>ISSN: 0301-4622</identifier><identifier>EISSN: 1873-4200</identifier><identifier>DOI: 10.1016/j.bpc.2006.08.001</identifier><identifier>PMID: 16952419</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Calcium - metabolism ; Calcium Signaling - physiology ; Chemical Langevin equation ; Cytosol - metabolism ; Finite molecule number ; Inositol 1,4,5-Trisphosphate - physiology ; Intracellular calcium oscillations ; Models, Biological ; Oscillometry ; Stochastic Processes</subject><ispartof>Biophysical chemistry, 2007, Vol.125 (1), p.201-212</ispartof><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-3a32ca7e29f8abf96a10a7bcb41477e66640bcc79b2ee969b27a36ea1b33d5b03</citedby><cites>FETCH-LOGICAL-c382t-3a32ca7e29f8abf96a10a7bcb41477e66640bcc79b2ee969b27a36ea1b33d5b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16952419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Chun-lian</creatorcontrib><creatorcontrib>Jia, Ya</creatorcontrib><creatorcontrib>Liu, Quan</creatorcontrib><creatorcontrib>Yang, Li-jian</creatorcontrib><creatorcontrib>Zhan, Xuan</creatorcontrib><title>A mesoscopic stochastic mechanism of cytosolic calcium oscillations</title><title>Biophysical chemistry</title><addtitle>Biophys Chem</addtitle><description>Based on a model of intracellular calcium (Ca
2+) oscillation with self-modulation of inositol 1,4,5-trisphosphate signal, the mesoscopic stochastic differential equations for the intracellular Ca
2+ oscillations are theoretically derived by using the chemical Langevin equation method. The effects of the finite biochemical reaction molecule number on both simple and complex cytosolic Ca
2+ oscillations are numerically studied. In the case of simple intracellular Ca
2+ oscillation, it is found that, with the increase of molecule number, the coherence resonance or autonomous resonance phenomena can occur for some external stimulation parameter values. In the cases of complex cytosolic Ca
2+ oscillations, each extremum of concentration of cytosolic Ca
2+ oscillations corresponds to a peak in the histogram of Ca
2+ concentration, and the most probability appeared during the bursting plateau level for bursting, but at the largest minimum of Ca
2+ concentration for chaos. For quasi-periodicity, however, there are only two peaks in the histogram of Ca
2+ concentration, and the most probability is located at low concentration state.</description><subject>Calcium - metabolism</subject><subject>Calcium Signaling - physiology</subject><subject>Chemical Langevin equation</subject><subject>Cytosol - metabolism</subject><subject>Finite molecule number</subject><subject>Inositol 1,4,5-Trisphosphate - physiology</subject><subject>Intracellular calcium oscillations</subject><subject>Models, Biological</subject><subject>Oscillometry</subject><subject>Stochastic Processes</subject><issn>0301-4622</issn><issn>1873-4200</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkE9LAzEQxYMotlY_gBfpyduuk2Sb7OKpFP9BwYueQzI7iym7Td3sCn57U1rwpnOZ4fHmMfNj7JpDzoGru03udpgLAJVDmQPwEzblpZZZkbRTNgUJPCuUEBN2EeMGUpUA52zCVbUQBa-mbLWcdxRDxLDzOI9DwA8bhzR2lKatj908NHP8HkIMbZLRtujHJEb0bWsHH7bxkp01to10dewz9v748LZ6ztavTy-r5TpDWYohk1YKtJpE1ZTWNZWyHKx26ApeaE1KqQIcoq6cIKpUatpKRZY7KeuFAzljt4fcXR8-R4qD6XxESmdsKYzRqFIupIbyXyNP30stdDLygxH7EGNPjdn1vrP9t-Fg9ojNxiTEZo_YQGkS4rRzcwwfXUf178aRaTLcHwyUWHx56k1iRVuk2veEg6mD_yP-B_m-jHo</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Zhu, Chun-lian</creator><creator>Jia, Ya</creator><creator>Liu, Quan</creator><creator>Yang, Li-jian</creator><creator>Zhan, Xuan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>A mesoscopic stochastic mechanism of cytosolic calcium oscillations</title><author>Zhu, Chun-lian ; Jia, Ya ; Liu, Quan ; Yang, Li-jian ; Zhan, Xuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-3a32ca7e29f8abf96a10a7bcb41477e66640bcc79b2ee969b27a36ea1b33d5b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Calcium - metabolism</topic><topic>Calcium Signaling - physiology</topic><topic>Chemical Langevin equation</topic><topic>Cytosol - metabolism</topic><topic>Finite molecule number</topic><topic>Inositol 1,4,5-Trisphosphate - physiology</topic><topic>Intracellular calcium oscillations</topic><topic>Models, Biological</topic><topic>Oscillometry</topic><topic>Stochastic Processes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Chun-lian</creatorcontrib><creatorcontrib>Jia, Ya</creatorcontrib><creatorcontrib>Liu, Quan</creatorcontrib><creatorcontrib>Yang, Li-jian</creatorcontrib><creatorcontrib>Zhan, Xuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biophysical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Chun-lian</au><au>Jia, Ya</au><au>Liu, Quan</au><au>Yang, Li-jian</au><au>Zhan, Xuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mesoscopic stochastic mechanism of cytosolic calcium oscillations</atitle><jtitle>Biophysical chemistry</jtitle><addtitle>Biophys Chem</addtitle><date>2007</date><risdate>2007</risdate><volume>125</volume><issue>1</issue><spage>201</spage><epage>212</epage><pages>201-212</pages><issn>0301-4622</issn><eissn>1873-4200</eissn><abstract>Based on a model of intracellular calcium (Ca
2+) oscillation with self-modulation of inositol 1,4,5-trisphosphate signal, the mesoscopic stochastic differential equations for the intracellular Ca
2+ oscillations are theoretically derived by using the chemical Langevin equation method. The effects of the finite biochemical reaction molecule number on both simple and complex cytosolic Ca
2+ oscillations are numerically studied. In the case of simple intracellular Ca
2+ oscillation, it is found that, with the increase of molecule number, the coherence resonance or autonomous resonance phenomena can occur for some external stimulation parameter values. In the cases of complex cytosolic Ca
2+ oscillations, each extremum of concentration of cytosolic Ca
2+ oscillations corresponds to a peak in the histogram of Ca
2+ concentration, and the most probability appeared during the bursting plateau level for bursting, but at the largest minimum of Ca
2+ concentration for chaos. For quasi-periodicity, however, there are only two peaks in the histogram of Ca
2+ concentration, and the most probability is located at low concentration state.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16952419</pmid><doi>10.1016/j.bpc.2006.08.001</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biophysical chemistry, 2007, Vol.125 (1), p.201-212 |
| issn | 0301-4622 1873-4200 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68353708 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Calcium - metabolism Calcium Signaling - physiology Chemical Langevin equation Cytosol - metabolism Finite molecule number Inositol 1,4,5-Trisphosphate - physiology Intracellular calcium oscillations Models, Biological Oscillometry Stochastic Processes |
| title | A mesoscopic stochastic mechanism of cytosolic calcium oscillations |
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