Interleukin-17 Expression in the Human Placenta

Abstract Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit,...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2007-01, Vol.28 (1), p.59-63
Main Authors: Pongcharoen, S, Somran, J, Sritippayawan, S, Niumsup, P, Chanchan, P, Butkhamchot, P, Tatiwat, P, Kunngurn, S, Searle, R.F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cells, Cultured
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Gene Expression
Human
Humans
IL-17 expression
IL-17 mRNA
Interleukin-17 - metabolism
Internal Medicine
Obstetrics and Gynecology
Placenta
Placenta - chemistry
Placenta - metabolism
Pregnancy
Pregnancy Proteins - analysis
RNA, Messenger - analysis
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Summary:Abstract Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA and protein in human placental tissues was investigated. IL-17 mRNA was expressed by purified cytokeratin-positive term placental trophoblast cells, HLA-G+ extravillous trophoblast cells and placental macrophages (Hofbauer cells). IL-17 localized in both cyto- and syncytiotrophoblasts of normal term pregnancy, spontaneous miscarriage and in molar pregnancy. In spontaneous miscarriage and molar pregnancy extravillous trophoblast cells were consistently immunoreactive for IL-17. IL-17 expression in human placenta may play a key role in angiogenesis and/or immunoregulation in the establishment of pregnancy.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2006.01.016