Prenatal Vitamin C Status is Associated with Placental Apoptosis in Normal-term Human Pregnancies

Abstract Pregnancy is associated with increased susceptibility to oxidative stress. Deficiencies in antioxidants during pregnancy and placental oxidant–antioxidant imbalance may impair the development of the fetoplacental unit or the eventual offspring. In order to elucidate the association of prena...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2007-01, Vol.28 (1), p.31-38
Main Authors: Ahn, Y.M, Kim, Y.J, Park, H, Park, B, Lee, H
Format: Article
Language:English
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Summary:Abstract Pregnancy is associated with increased susceptibility to oxidative stress. Deficiencies in antioxidants during pregnancy and placental oxidant–antioxidant imbalance may impair the development of the fetoplacental unit or the eventual offspring. In order to elucidate the association of prenatal status of vitamin C with the oxidative stress and apoptotic activity in normal full-term placentas, we evaluated the content of placental lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and the trophoblast apoptotic index in normal-term human pregnancies. Tissue samples of placentas obtained from 80 normal-term pregnancies were categorized into 40 cases with a lower level of prenatal vitamin C (
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2006.01.018