Prenatal Vitamin C Status is Associated with Placental Apoptosis in Normal-term Human Pregnancies

Abstract Pregnancy is associated with increased susceptibility to oxidative stress. Deficiencies in antioxidants during pregnancy and placental oxidant–antioxidant imbalance may impair the development of the fetoplacental unit or the eventual offspring. In order to elucidate the association of prena...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2007-01, Vol.28 (1), p.31-38
Main Authors: Ahn, Y.M, Kim, Y.J, Park, H, Park, B, Lee, H
Format: Article
Language:English
Subjects:
Adult
Apoptosis
Ascorbic Acid - blood
Biological and medical sciences
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Humans
Internal Medicine
Obstetrics and Gynecology
Oxidative Stress
Placenta
Placenta - metabolism
Placenta - physiology
Pregnancy
Scavenger Receptors, Class E - metabolism
Term Birth - blood
Term Birth - metabolism
Trophoblast
Trophoblasts - physiology
Vitamin C
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Summary:Abstract Pregnancy is associated with increased susceptibility to oxidative stress. Deficiencies in antioxidants during pregnancy and placental oxidant–antioxidant imbalance may impair the development of the fetoplacental unit or the eventual offspring. In order to elucidate the association of prenatal status of vitamin C with the oxidative stress and apoptotic activity in normal full-term placentas, we evaluated the content of placental lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and the trophoblast apoptotic index in normal-term human pregnancies. Tissue samples of placentas obtained from 80 normal-term pregnancies were categorized into 40 cases with a lower level of prenatal vitamin C (
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2006.01.018