Extrathymic rearrangement of alphabetaT-lymphocyte antigen receptor genes during pregnancy

The existence of alphabetaT-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearr...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2007-09, Vol.72 (9), p.983-988
Main Authors: Shirshev, S V, Kuklina, E M, Maksimov, A Yu, Krapivina, O A, Parshakova, N S
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Female
Gene Rearrangement, T-Lymphocyte
Homeodomain Proteins - biosynthesis
Homeodomain Proteins - genetics
Lymph Nodes - cytology
Mice
Pregnancy
Pregnancy, Animal - genetics
Pregnancy, Animal - physiology
Receptors, Antigen, T-Cell, alpha-beta - physiology
RNA, Messenger - biosynthesis
T-Lymphocytes - cytology
T-Lymphocytes - metabolism
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Summary:The existence of alphabetaT-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearranged TCR alpha-chain (pre-TCRalpha) preferentially in T-lymphocytes of lymph nodes involved in uterine drainage (para-aortal lymph nodes), and to a lesser extent in other lymph nodes (mainly from axillary lymph nodes). The data suggest that during pregnancy the differentiation of alphabetaT lymphocytes may occur not only in central (thymus) but also in peripheral lymphoid organs.
ISSN:0006-2979