Loading…

Extrathymic rearrangement of alphabetaT-lymphocyte antigen receptor genes during pregnancy

The existence of alphabetaT-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearr...

Full description

Saved in:

Bibliographic Details
Published in:	Biochemistry (Moscow) 2007-09, Vol.72 (9), p.983-988
Main Authors:	Shirshev, S V, Kuklina, E M, Maksimov, A Yu, Krapivina, O A, Parshakova, N S
Format:	Article
Language:	English
Subjects:	Animals Cell Differentiation Female Gene Rearrangement, T-Lymphocyte Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Lymph Nodes - cytology Mice Pregnancy Pregnancy, Animal - genetics Pregnancy, Animal - physiology Receptors, Antigen, T-Cell, alpha-beta - physiology RNA, Messenger - biosynthesis T-Lymphocytes - cytology T-Lymphocytes - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by
cites
container_end_page	988
container_issue	9
container_start_page	983
container_title	Biochemistry (Moscow)
container_volume	72
creator	Shirshev, S V Kuklina, E M Maksimov, A Yu Krapivina, O A Parshakova, N S
description	The existence of alphabetaT-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearranged TCR alpha-chain (pre-TCRalpha) preferentially in T-lymphocytes of lymph nodes involved in uterine drainage (para-aortal lymph nodes), and to a lesser extent in other lymph nodes (mainly from axillary lymph nodes). The data suggest that during pregnancy the differentiation of alphabetaT lymphocytes may occur not only in central (thymus) but also in peripheral lymphoid organs.
format	article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68356414</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68356414</sourcerecordid><originalsourceid>FETCH-LOGICAL-p547-dfbac2a6568f86de5b697455ba1e4e61eabaae6083e4a0d4790400364f25dc773</originalsourceid><addsrcrecordid>eNo1kDtrwzAURjW0NGnav1A0dTPIsh72WEL6gEAWT13MtXz9KLasSjLU_76GptPHgcMZvhuyZ4yphBe62JH7EL425KzI7sgu1QXnSuo9-Tz9RA-xX6fBUI_gPdgOJ7SRzi2F0fVQY4QyGdfJ9bNZI1KwcejQbrpBF2dPN8BAm8UPtqPOY2fBmvWB3LYwBny87oGUr6fy-J6cL28fx5dz4qTQSdPWYDgoqfI2Vw3KWhVaSFlDigJVilADoGJ5hgJYI3TBBGOZEi2XjdE6O5Dnv6zz8_eCIVbTEAyOI1icl1CpPJNKpGITn67iUk_YVM4PE_i1-j8j-wXpqVx7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68356414</pqid></control><display><type>article</type><title>Extrathymic rearrangement of alphabetaT-lymphocyte antigen receptor genes during pregnancy</title><source>Springer Nature</source><creator>Shirshev, S V ; Kuklina, E M ; Maksimov, A Yu ; Krapivina, O A ; Parshakova, N S</creator><creatorcontrib>Shirshev, S V ; Kuklina, E M ; Maksimov, A Yu ; Krapivina, O A ; Parshakova, N S</creatorcontrib><description>The existence of alphabetaT-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearranged TCR alpha-chain (pre-TCRalpha) preferentially in T-lymphocytes of lymph nodes involved in uterine drainage (para-aortal lymph nodes), and to a lesser extent in other lymph nodes (mainly from axillary lymph nodes). The data suggest that during pregnancy the differentiation of alphabetaT lymphocytes may occur not only in central (thymus) but also in peripheral lymphoid organs.</description><identifier>ISSN: 0006-2979</identifier><identifier>PMID: 17922657</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Cell Differentiation ; Female ; Gene Rearrangement, T-Lymphocyte ; Homeodomain Proteins - biosynthesis ; Homeodomain Proteins - genetics ; Lymph Nodes - cytology ; Mice ; Pregnancy ; Pregnancy, Animal - genetics ; Pregnancy, Animal - physiology ; Receptors, Antigen, T-Cell, alpha-beta - physiology ; RNA, Messenger - biosynthesis ; T-Lymphocytes - cytology ; T-Lymphocytes - metabolism</subject><ispartof>Biochemistry (Moscow), 2007-09, Vol.72 (9), p.983-988</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17922657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shirshev, S V</creatorcontrib><creatorcontrib>Kuklina, E M</creatorcontrib><creatorcontrib>Maksimov, A Yu</creatorcontrib><creatorcontrib>Krapivina, O A</creatorcontrib><creatorcontrib>Parshakova, N S</creatorcontrib><title>Extrathymic rearrangement of alphabetaT-lymphocyte antigen receptor genes during pregnancy</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry (Mosc)</addtitle><description>The existence of alphabetaT-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearranged TCR alpha-chain (pre-TCRalpha) preferentially in T-lymphocytes of lymph nodes involved in uterine drainage (para-aortal lymph nodes), and to a lesser extent in other lymph nodes (mainly from axillary lymph nodes). The data suggest that during pregnancy the differentiation of alphabetaT lymphocytes may occur not only in central (thymus) but also in peripheral lymphoid organs.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Female</subject><subject>Gene Rearrangement, T-Lymphocyte</subject><subject>Homeodomain Proteins - biosynthesis</subject><subject>Homeodomain Proteins - genetics</subject><subject>Lymph Nodes - cytology</subject><subject>Mice</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - genetics</subject><subject>Pregnancy, Animal - physiology</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - physiology</subject><subject>RNA, Messenger - biosynthesis</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - metabolism</subject><issn>0006-2979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNo1kDtrwzAURjW0NGnav1A0dTPIsh72WEL6gEAWT13MtXz9KLasSjLU_76GptPHgcMZvhuyZ4yphBe62JH7EL425KzI7sgu1QXnSuo9-Tz9RA-xX6fBUI_gPdgOJ7SRzi2F0fVQY4QyGdfJ9bNZI1KwcejQbrpBF2dPN8BAm8UPtqPOY2fBmvWB3LYwBny87oGUr6fy-J6cL28fx5dz4qTQSdPWYDgoqfI2Vw3KWhVaSFlDigJVilADoGJ5hgJYI3TBBGOZEi2XjdE6O5Dnv6zz8_eCIVbTEAyOI1icl1CpPJNKpGITn67iUk_YVM4PE_i1-j8j-wXpqVx7</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Shirshev, S V</creator><creator>Kuklina, E M</creator><creator>Maksimov, A Yu</creator><creator>Krapivina, O A</creator><creator>Parshakova, N S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>Extrathymic rearrangement of alphabetaT-lymphocyte antigen receptor genes during pregnancy</title><author>Shirshev, S V ; Kuklina, E M ; Maksimov, A Yu ; Krapivina, O A ; Parshakova, N S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p547-dfbac2a6568f86de5b697455ba1e4e61eabaae6083e4a0d4790400364f25dc773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Female</topic><topic>Gene Rearrangement, T-Lymphocyte</topic><topic>Homeodomain Proteins - biosynthesis</topic><topic>Homeodomain Proteins - genetics</topic><topic>Lymph Nodes - cytology</topic><topic>Mice</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - genetics</topic><topic>Pregnancy, Animal - physiology</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - physiology</topic><topic>RNA, Messenger - biosynthesis</topic><topic>T-Lymphocytes - cytology</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shirshev, S V</creatorcontrib><creatorcontrib>Kuklina, E M</creatorcontrib><creatorcontrib>Maksimov, A Yu</creatorcontrib><creatorcontrib>Krapivina, O A</creatorcontrib><creatorcontrib>Parshakova, N S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry (Moscow)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shirshev, S V</au><au>Kuklina, E M</au><au>Maksimov, A Yu</au><au>Krapivina, O A</au><au>Parshakova, N S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extrathymic rearrangement of alphabetaT-lymphocyte antigen receptor genes during pregnancy</atitle><jtitle>Biochemistry (Moscow)</jtitle><addtitle>Biochemistry (Mosc)</addtitle><date>2007-09</date><risdate>2007</risdate><volume>72</volume><issue>9</issue><spage>983</spage><epage>988</epage><pages>983-988</pages><issn>0006-2979</issn><abstract>The existence of alphabetaT-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearranged TCR alpha-chain (pre-TCRalpha) preferentially in T-lymphocytes of lymph nodes involved in uterine drainage (para-aortal lymph nodes), and to a lesser extent in other lymph nodes (mainly from axillary lymph nodes). The data suggest that during pregnancy the differentiation of alphabetaT lymphocytes may occur not only in central (thymus) but also in peripheral lymphoid organs.</abstract><cop>United States</cop><pmid>17922657</pmid><tpages>6</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0006-2979
ispartof	Biochemistry (Moscow), 2007-09, Vol.72 (9), p.983-988
issn	0006-2979
language	eng
recordid	cdi_proquest_miscellaneous_68356414
source	Springer Nature
subjects	Animals Cell Differentiation Female Gene Rearrangement, T-Lymphocyte Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Lymph Nodes - cytology Mice Pregnancy Pregnancy, Animal - genetics Pregnancy, Animal - physiology Receptors, Antigen, T-Cell, alpha-beta - physiology RNA, Messenger - biosynthesis T-Lymphocytes - cytology T-Lymphocytes - metabolism
title	Extrathymic rearrangement of alphabetaT-lymphocyte antigen receptor genes during pregnancy
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T19%3A28%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extrathymic%20rearrangement%20of%20alphabetaT-lymphocyte%20antigen%20receptor%20genes%20during%20pregnancy&rft.jtitle=Biochemistry%20(Moscow)&rft.au=Shirshev,%20S%20V&rft.date=2007-09&rft.volume=72&rft.issue=9&rft.spage=983&rft.epage=988&rft.pages=983-988&rft.issn=0006-2979&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E68356414%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p547-dfbac2a6568f86de5b697455ba1e4e61eabaae6083e4a0d4790400364f25dc773%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=68356414&rft_id=info:pmid/17922657&rfr_iscdi=true