Large changes in regulome size herald the main prokaryotic lineages

Using a large-scale reconstruction of ancestral gene content, we show that radical changes in regulome size occur at the origins of major prokaryotic lineages. Subsequently, the duplication and deletion of regulators slows down in most lineages, except proteobacteria, significantly reducing the scal...

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Bibliographic Details
Published in:Trends in genetics 2007-10, Vol.23 (10), p.488-493
Main Authors: Cordero, Otto X, Hogeweg, P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological evolution
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Genome
Medical Education
Molecular and cellular biology
Prokaryotic Cells
Proteobacteria
Proteobacteria - genetics
Proteobacteria - metabolism
Proteome
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Summary:Using a large-scale reconstruction of ancestral gene content, we show that radical changes in regulome size occur at the origins of major prokaryotic lineages. Subsequently, the duplication and deletion of regulators slows down in most lineages, except proteobacteria, significantly reducing the scaling of regulators and keeping their average proportion lineage-specific. Our results also suggest that major transitions in prokaryote evolution are related to changes in regulatory capacity rather than proteome innovations.
ISSN:0168-9525
DOI:10.1016/j.tig.2007.07.006