Semliki Forest virus vectors expressing the H and HN genes of measles and mumps viruses reduce immunity induced by the envelope protein genes of rubella virus

Abstract A Semliki Forest virus (SFV) recombinant particle vaccine vector was constructed expressing the viral E1 and E2 envelope proteins of the RA27/3 vaccine strain of rubella virus. This vector induced high titres of antibody after intramuscular administration to Balb/C mice, both following init...

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Bibliographic Details
Published in:Vaccine 2007-10, Vol.25 (43), p.7481-7490
Main Authors: Callagy, Sara J, Kelly, Barbara J, Fleeton, Marina N, Sheahan, Brian J, Galbraith, Sareen E, Atkins, Gregory J
Format: Article
Language:English
Subjects:
Agglutination Tests
Allergy and Immunology
Animals
Antibodies, Viral - blood
Antigens, Viral - genetics
Antigens, Viral - immunology
Applied microbiology
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
Female
Fundamental and applied biological sciences. Psychology
Genes
Genetic Vectors - administration & dosage
Genetic Vectors - genetics
Human viral diseases
Immune response
Infections
Infectious diseases
Injections, Intramuscular
Lymphocytes
Measles
Measles virus
Measles virus - genetics
Medical research
Medical sciences
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Multivalent vaccines
Mumps
Mumps virus
Mumps virus - genetics
Proteins
Rubella virus
Rubella virus - genetics
Semliki Forest virus
Semliki forest virus - genetics
Semliki Forest virus vector
Vaccination - methods
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Viral Envelope Proteins - genetics
Viral Envelope Proteins - immunology
Virology
Viruses
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Description
Summary:Abstract A Semliki Forest virus (SFV) recombinant particle vaccine vector was constructed expressing the viral E1 and E2 envelope proteins of the RA27/3 vaccine strain of rubella virus. This vector induced high titres of antibody after intramuscular administration to Balb/C mice, both following initial vaccination and a boost 4 weeks later. This occurred for antibody as measured by ELISA and as measured by a latex agglutination test. However, co-administration of similar particles expressing the measles virus H protein and the mumps virus HN protein with the rubella protein expressing vector resulted in reduction of the anti-rubella immune response.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2007.08.049