The catechol O -methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia

Abstract Background A valine/methionine polymorphism of the catechol O -methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studie...

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Bibliographic Details
Published in:Schizophrenia research 2007-11, Vol.96 (1), p.87-92
Main Authors: Dickerson, Faith B, Boronow, John J, Stallings, Cassie, Origoni, Andrea E, Sullens, Anne, Yolken, Robert H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amino Acid Substitution
Antipsychotic Agents - therapeutic use
Catechol O-Methyltransferase - genetics
Cognition
Cognition - physiology
COMT
Genetic
Humans
Methionine
Middle Aged
Neuropsychological Tests
Polymorphism, Genetic
Psychiatry
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - genetics
Schizophrenic Psychology
Valine
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Summary:Abstract Background A valine/methionine polymorphism of the catechol O -methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. The association between the COMT polymorphism and other cognitive domains has been the focus of only limited investigation. Methods We measured COMT Val158Met genotypes in N = 364 individuals with schizophrenia. Cognitive functioning was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We employed univariate and multivariate analyses of variance to determine the association between COMT genotypes and the RBANS index and individual test scores. Results There was no significant association between the COMT Val158Met genotypes and any of the RBANS index or individual test scores measured in either univariate or multivariate analyses (all p > .3). Conclusion Based on the results in our sample, the catechol O -methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2007.05.021