Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH

Abstract We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberration...

Full description

Saved in:
Bibliographic Details
Published in:Leukemia research 2007-01, Vol.31 (1), p.39-47
Main Authors: Babicka, Libuse, Ransdorfova, Sarka, Brezinova, Jana, Zemanova, Zuzana, Sindelarova, Lenka, Siskova, Magda, Maaloufova, Jacqueline, Cermak, Jaroslav, Michalova, Kyra
Format: Article
Language:English
Subjects:
Adult
Aged
AML
Bone Marrow Cells - pathology
Bone Marrow Cells - physiology
Chromosome Aberrations
Chromosomes, Human - genetics
Complex chromosomal aberrations
Female
Gene Rearrangement - genetics
Hematology, Oncology and Palliative Medicine
History, 16th Century
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Male
mBAND
MDS
mFISH
Middle Aged
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or 11 was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients—16.2%) and the most frequent breakpoints 5q13, 5q33, 7q31, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2006.03.010