Anti-osteoporotic effect of Erythrina variegata L. in ovariectomized rats

The present study was designed to investigate whether Erythrina variegata L. (EV), which belongs to the leguminous family, exerted any beneficial effects on bone in ovariectomized rats. Daily oral administration of the EV extract at 300 and 600 mg/kg for 14 weeks to rats prevented the OVX-induced in...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2007-01, Vol.109 (1), p.165-169
Main Authors: Zhang, Yan, Li, Xiao-Li, Lai, Wan-Ping, Chen, Bin, Chow, Hung-Kay, Wu, Chun-Fu, Wang, Nai-Li, Yao, Xin-Sheng, Wong, Man-Sau
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomarkers
Biomechanical Phenomena
Body Weight - drug effects
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone and Bones - pathology
Bone Density Conservation Agents - pharmacology
Chromatography, High Pressure Liquid
Erythrina - chemistry
Erythrina variegata L
Female
Femur - drug effects
Femur - physiology
General pharmacology
Genistein
Genistein - blood
Medical sciences
Organ Size - drug effects
Osteoporosis
Osteoporosis - pathology
Osteoporosis - prevention & control
Ovariectomy
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytoestrogen
Phytotherapy
Plant Bark - chemistry
Rats
Rats, Sprague-Dawley
Spectrophotometry, Ultraviolet
Tibia - drug effects
Tibia - physiology
Uterus - drug effects
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Summary:The present study was designed to investigate whether Erythrina variegata L. (EV), which belongs to the leguminous family, exerted any beneficial effects on bone in ovariectomized rats. Daily oral administration of the EV extract at 300 and 600 mg/kg for 14 weeks to rats prevented the OVX-induced increase in the serum OCN, ALP, and urinary DPD levels. Histomorphometric analysis of the proximal end of the tibia showed that the EV extract prevented the estrogen deficiency-induced decrease in trabecular thickness and trabecular area, as well as restoring the increase in trabecular separation in a dose-dependent manner. Moreover, the EV extract improved the energy absorption and stiffness of the mid-shaft of the rat femur. Thus, the present study clearly demonstrated that EV could suppress the high rate of bone turnover induced by estrogen deficiency, inhibit bone loss and improve the biomechanical properties of bone in the OVX rats.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2006.07.005