Influence of TRPV3 mutation on hair growth cycle in mice

We recently reported that Gly573Ser substitution of the transient receptor potential cation channel, subfamily V member 3 (TRPV3) caused hair loss in DS- Nh mice. To further elucidate the effects of this mutation on the development of the spontaneous hairless phenotype, we examined the temperature–r...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2007-11, Vol.363 (3), p.479-483
Main Authors: Imura, Kinichi, Yoshioka, Takeshi, Hikita, Ichiro, Tsukahara, Kiyoshi, Hirasawa, Tsutomu, Higashino, Kenichi, Gahara, Yoshinari, Arimura, Akinori, Sakata, Tsuneaki
Format: Article
Language:English
Subjects:
Anagen
Animals
Biological Transport
Calcium - metabolism
Calcium - pharmacokinetics
DS- Nh
Epidermis - cytology
Epidermis - metabolism
Female
Gene Expression Profiling
Hair - growth & development
Hair - metabolism
Hair Follicle - growth & development
Hair Follicle - metabolism
Hair-growth cycle
Male
Mice
Mice, Hairless
Mutation
Oligonucleotide Array Sequence Analysis
Phenotype
Reverse Transcriptase Polymerase Chain Reaction
Time Factors
TRPV Cation Channels - genetics
TRPV Cation Channels - physiology
TRPV3
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Summary:We recently reported that Gly573Ser substitution of the transient receptor potential cation channel, subfamily V member 3 (TRPV3) caused hair loss in DS- Nh mice. To further elucidate the effects of this mutation on the development of the spontaneous hairless phenotype, we examined the temperature–response to epidermal sheets from DS- Nh and DS mice. It was indicated that the mutation was gain-of-function. We also performed genetic and histological analyses with both strain skins. DNA microarray data revealed that the levels of keratin-associated protein 16-1, 16-3, and 16-9 genes related to the anagen phase were decreased in the skins of DS- Nh mice compared with those of three days old DS mice. Histological analysis revealed that the anagen phase persisted in DS- Nh mice, and that the telogen phase was seen in DS but not DS- Nh mice at 21 days of age. Regulation of TRPV3 appears to be important for appropriate hair development in rodents.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2007.08.170