Luteinizing hormone pulsatility in patients with major ovarian hyperandrogenism

Hyperandrogenism and ovulatory dysfunction are common in women with either polycystic ovary (PCOS) or ovarian virilizing tumor. However, contrasting with the numerous studies that have extensively described gonadotropin secretory abnormalities, principally increased LH pulse amplitude and frequency,...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2007-09, Vol.30 (8), p.636-646
Main Authors: Bachelot, A, Laborde, K, Bresson, J L, Plu-Bureau, G, Raynaud, A, Bertagna, X, Mogenet, A, Mansour, M, Lucas-Jouy, V, Gayno, J-P, Reznik, Y, Kuhn, J-M, Billaud, L, Vacher-Lavenu, M-C, Putterman, M, Mowszowicz, I, Touraine, P, Kuttenn, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Feedback, Physiological
Female
Follicle Stimulating Hormone - blood
Humans
Hyperandrogenism - metabolism
Luteinizing Hormone - blood
Polycystic Ovary Syndrome - metabolism
Pulsatile Flow
Testosterone - blood
Virilism - metabolism
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Summary:Hyperandrogenism and ovulatory dysfunction are common in women with either polycystic ovary (PCOS) or ovarian virilizing tumor. However, contrasting with the numerous studies that have extensively described gonadotropin secretory abnormalities, principally increased LH pulse amplitude and frequency, few studies have concerned gonadotropin secretion in patients with ovarian virilizing tumors; low gonadotropin levels have occasionally been reported, but never extensively studied. The goal of the present study was to further evaluate the pulsatility of LH secretion in women with ovarian virilizing tumor compared with that of PCOS patients. Eighteen women with major hyperandrogenism (plasma testosterone level >1.2 ng/ml) were studied (5 women with ovarian virilizing tumor, 13 women with PCOS, and 10 control women). Mean plasma LH level, LH pulse number and amplitude were dramatically low in patients with ovarian tumors when compared to both PCOS (p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03347443