Fully automated preparation of n.c.a. 4-[ 18F]fluorobenzoic acid and N-succinimidyl 4-[ 18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)

The widely used bifunctional labeling reagent 4-[ 18F]fluorobenzoic acid ([ 18F]FBA) and its activated form N-succinimidyl 4-[ 18F]fluorobenzoate ([ 18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [ 18F]FDG module. The products were obtained wi...

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Bibliographic Details
Published in:Applied radiation and isotopes 2007-02, Vol.65 (2), p.199-203
Main Authors: Marik, Jan, Sutcliffe, Julie L.
Format: Article
Language:English
Subjects:
4-[ 18F]fluorobenzoic acid
[ 18F]FBA
[ 18F]SFB
Benzoates - chemical synthesis
Chemistry process control unit (CPCU)
Fluorine Radioisotopes
Isotope Labeling
N-succinimidyl 4-[ 18F]fluorobenzoate
Positron emission tomography PET
Radiopharmaceuticals - chemical synthesis
Succinimides - chemical synthesis
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Summary:The widely used bifunctional labeling reagent 4-[ 18F]fluorobenzoic acid ([ 18F]FBA) and its activated form N-succinimidyl 4-[ 18F]fluorobenzoate ([ 18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [ 18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77±5% ( n=4) for [ 18F]FBA and 46±5% ( n=4) for [ 18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2006.06.007