PVP magnetic nanospheres: Biocompatibility, in vitro and in vivo bleomycin release

To synthesize and characterize a magnetic micromolecular delivery system based on PVP hydrogel with polyvinyl alcohol (PVA) as the crosslinker. The microparticles were successfully prepared using 25 kGy Co-60 γ-ray irradiation and characterized. Biocompatibility, in vitro and in vivo drug release te...

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Bibliographic Details
Published in:International journal of pharmaceutics 2007-01, Vol.328 (1), p.78-85
Main Authors: Guowei, Ding, Adriane, Kamulegeya, Chen, XingZai, Jie, Chen, Yinfeng, Liu
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - pharmacokinetics
Biocompatible Materials
Biological and medical sciences
Bleomycin - administration & dosage
Bleomycin - chemistry
Bleomycin - pharmacokinetics
Chromatography, High Pressure Liquid
Female
Gamma Rays
General pharmacology
Hemolysis - drug effects
Magnetic guided drug delivery
Magnetic micromolecules
Magnetics
Male
Materials Testing
Medical sciences
Mice
Mice, Inbred BALB C
Microscopy, Electron, Scanning Transmission
Nanoparticles
Nanospheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyvinyl Alcohol - chemistry
Polyvinylpyrrolidone (PVP) hydrogel
Povidone - chemistry
Rabbits
Reference Standards
Tetrazolium Salts
Thiazoles
Tissue Distribution
Citations: Items that cite this one
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Description
Summary:To synthesize and characterize a magnetic micromolecular delivery system based on PVP hydrogel with polyvinyl alcohol (PVA) as the crosslinker. The microparticles were successfully prepared using 25 kGy Co-60 γ-ray irradiation and characterized. Biocompatibility, in vitro and in vivo drug release tests were carried out. Bleomycin was quantitatively released with in slightly over 8 h (hours) from the nanospheres containing 1 mg bleomycin while the time was longer for those containing 5 mg. On the other hand free bleomycin quantitatively passed through the dialysis baffle with in only 3.5 h. For both 5 and 1 mg of bound bleomycin, it took up to 2 h to reach peak concentration compared to 30 min for the free drug. The PVP hydrogel magnetic nanospheres exhibited passive drug release that could be exploited to enhance therapeutic efficacy. The present results indicate that PVP hydrogel based magnetic nanospheres have potential as drug carriers in magnetic guided chemotherapeutic drug delivery.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2006.07.042