One-year results of photodynamic therapy for small predominantly classic choroidal neovascular membranes secondary to age-related macular degeneration

• Published in: European journal of ophthalmology 2007-09, Vol.17 (5), p.760-767
• Main Authors: Doyle, E, Khanwala, M, Shah, S P, Ong, D G, Casswell, A G
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Choroidal Neovascularization - drug therapy; Choroidal Neovascularization - etiology; Choroidal Neovascularization - pathology; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Humans; Macular Degeneration - complications; Macular Degeneration - pathology; Middle Aged; Photochemotherapy - methods; Photosensitizing Agents - therapeutic use; Porphyrins - therapeutic use; Prospective Studies; Time Factors; Treatment Outcome; Visual Acuity
• ISSN: 1120-6721; 1724-6016
• DOI: 10.1177/112067210701700512

To determine the visual and angiographic outcomes of patients with small predominantly classic choroidal neovascular membranes (CNV) undergoing photodynamic therapy (PDT). The subjects were a cohort of patients with age-related predominantly classic CNV with lesion size of greatest linear diameter of 2000 microm or less treated with PDT. Lesion size and visual acuity were recorded at baseline and at 3-month intervals. Visual treatment failure was defined as either loss of at least 15 letters or visual acuity less than 35 letters on a modified Early Treatment Diabetic Retinopathy Study chart. Lesion treatment failure was defined as increase in greatest linear diameter (GLD) of at least 500 microm. Twenty-five eyes of 25 patients were included. Visual treatment failure occurred in 16 and mean visual acuity dropped from 58 letters to 34 letters (p