Obstetric complications in patients with hereditary thrombophilia identified using the LCx microparticle enzyme immunoassay : A controlled study of 5,000 patients

Factor V Leiden (FVL) and prothrombin (PT) G20210A mutations are associated with increased risk of deep venous thrombosis, pulmonary embolism, and obstetric complications. The development of inexpensive and reliable screening methods will assist in defining subpopulations of patients at risk who sho...

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Bibliographic Details
Published in:American journal of clinical pathology 2007, Vol.127 (1), p.68-75
Main Authors: KOCHER, Olivier, CIROVIC, Christine, WONG, Geoffrey, BAUER, Kenneth A, MALYNN, Elizabeth, ROWLAND, Charles M, BARE, Lance A, YOUNG, Bradford A, HENSLEE, Jerry G, LAFFLER, Thomas G, HUFF, Jeffrey B, KRUSKALL, Margot S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Boston - epidemiology
Case-Control Studies
Factor V - genetics
Female
Hematologic and hematopoietic diseases
Humans
Immunoenzyme Techniques - methods
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Platelet diseases and coagulopathies
Pregnancy
Pregnancy Complications, Hematologic - diagnosis
Pregnancy Outcome
Prevalence
Prothrombin - genetics
Thrombophilia - complications
Thrombophilia - diagnosis
Thrombophilia - epidemiology
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Summary:Factor V Leiden (FVL) and prothrombin (PT) G20210A mutations are associated with increased risk of deep venous thrombosis, pulmonary embolism, and obstetric complications. The development of inexpensive and reliable screening methods will assist in defining subpopulations of patients at risk who should undergo testing. We used a method, developed by Abbott Laboratories (Abbott Park, IL), to study 5,000 pregnant women and evaluated the association of obstetric complications with the presence of the FVL and PT G20210A mutations. We found a statistically significant association between FVL and stillbirth. There were also trends toward an association between FVL and placental abruption and between PT G20210A and intrauterine growth retardation. In addition, an association may exist between PT G20210A and preterm delivery for white women. All other parameters studied, including miscarriage and preeclampsia, did not show a statistically significant association with FVL or PT G20210A. These results confirm the association between genetic thrombophilia and selected obstetric complications.
ISSN:0002-9173
1943-7722
DOI:10.1309/JWL27GRGU71VP5QL