The effect of prepubertal ovariohysterectomy on spine 1 mineral density and mineral content in puppies: A preliminary study

• Published in: Research in veterinary science 2007-02, Vol.82 (1), p.105-109
• Main Authors: Ekici, H., Sontas, B.H., Toydemir, T.S.F., Senmevsim, Ö., Kabasakal, L., Imre, Y.
• Format: Article
• Language: English
• Subjects: adverse effects; animal health; Animals; blood chemistry; body weight; Bone density; Bone Density - physiology; Bone mineral density; bone mineralization; Bones; calcium; contraception; Dog; Dogs - physiology; Female; females; Hysterectomy - veterinary; lumbar spine; Lumbar Vertebrae - physiology; Lumbar vertebraes; mineral content; Older people; Osteoporosis; Ovariectomy - veterinary; phosphorus; Prepubertal gonadectomy; puppies; Sexual Maturation; spaying; Studies; Veterinary medicine
• ISSN: 0034-5288; 1532-2661
• DOI: 10.1016/j.rvsc.2006.07.001

This pilot study investigated early effects of prepubertal ovariohysterectomy on bone mineral density (BMD) and bone mineral content (BMC) of lumbar vertebraes (L2–L5 and L Total) and on serum biochemistry. Both prepubertal ovariohysterectomy (Group Po: n = 3) and sham surgery (Group Lp: n = 3) were performed at 10 weeks of age. Blood samplings, BMD and BMC measurements of L2, L3, L4, L5 and L Total were performed at 12, 16, 20 and 24 weeks of age. No significant difference ( P > 0.05) in BMD and BMC was observed between the groups during the experimental period. The difference in serum calcium and phosphorus concentrations was found to be statistically unsignificant ( P > 0.05). These results fail to demonstrate a difference in BMD and BMC of lumbar vertebraes (L2–L5) as well as serum calcium and phosphorus levels after prepubertal ovariohysterectomy until six months of age in mixed breed puppies, but they should be considered only descriptive because of the very low sample number and of the low power of the statistical analyses.