Desorption Atmospheric Pressure Photoionization

An ambient ionization technique for mass spectrometry, desorption atmospheric pressure photoionization (DAPPI), is presented, and its application to the rapid analysis of compounds of various polarities on surfaces is demonstrated. The DAPPI technique relies on a heated nebulizer microchip deliverin...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2007-10, Vol.79 (20), p.7867-7872
Main Authors: Haapala, Markus, Pól, Jaroslav, Saarela, Ville, Arvola, Ville, Kotiaho, Tapio, Ketola, Raimo A, Franssila, Sami, Kauppila, Tiina J, Kostiainen, Risto
Format: Article
Language:English
Subjects:
Acetaminophen - chemistry
Adsorption
Analytical chemistry
Atmospheric Pressure
Chemical bonds
Chemistry
Exact sciences and technology
Gases - chemistry
Ions - chemistry
Mass spectrometry
Nebulizers and Vaporizers
Photochemistry
Semiconductors
Sensitivity and Specificity
Solvents
Spectrometric and optical methods
Temperature
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Summary:An ambient ionization technique for mass spectrometry, desorption atmospheric pressure photoionization (DAPPI), is presented, and its application to the rapid analysis of compounds of various polarities on surfaces is demonstrated. The DAPPI technique relies on a heated nebulizer microchip delivering a heated jet of vaporized solvent, e.g., toluene, and a photoionization lamp emitting 10-eV photons. The solvent jet is directed toward sample spots on a surface, causing the desorption of analytes from the surface. The photons emitted by the lamp ionize the analytes, which are then directed into the mass spectrometer. The limits of detection obtained with DAPPI were in the range of 56−670 fmol. Also, the direct analysis of pharmaceuticals from a tablet surface was successfully demonstrated. A comparison of the performance of DAPPI with that of the popular desorption electrospray ionization method was done with four standard compounds. DAPPI was shown to be equally or more sensitive especially in the case of less polar analytes.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac071152g