Evaluation of persistent pulmonary infiltrates in pediatric oncology patients

Purpose To evaluate the role of bronchoalveolar lavage (BAL), computed‐tomography‐guided biopsy (CTB), and open lung biopsy (OLB) in the management of persistent pulmonary infiltrates in pediatric oncology patients. Methods Retrospective review of clinical records of pediatric oncology patients who...

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Bibliographic Details
Published in:Pediatric blood & cancer 2007-02, Vol.48 (2), p.165-172
Main Authors: Armenian, Saro H., La Via, William V., Siegel, Stuart E., Mascarenhas, Leo
Format: Article
Language:English
Subjects:
BAL
Biopsy
Bone Marrow Transplantation - adverse effects
Bronchoalveolar Lavage
Child
Humans
infection
infiltrate
Lung - pathology
Lung Diseases - pathology
Neoplasms - complications
Neoplasms - pathology
oncology
pediatric
pulmonary
Regression Analysis
Retrospective Studies
Tomography, X-Ray Computed
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Summary:Purpose To evaluate the role of bronchoalveolar lavage (BAL), computed‐tomography‐guided biopsy (CTB), and open lung biopsy (OLB) in the management of persistent pulmonary infiltrates in pediatric oncology patients. Methods Retrospective review of clinical records of pediatric oncology patients who underwent BAL, CTB, and OLB over a 7‐year period. Data was compared across the three procedures using chi‐square analysis. Logistic regression was used to adjust potential confounding variables for diagnostic yield. Results There were 113 consecutive patients who underwent 140 separate procedures during their hospitalization. Thirty (26%) patients had a previous BMT. BALs were more likely to occur as the first line of investigation (98% vs. 47%, 45%; P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.20747