Amygdala control of emotion-induced forgetting and remembering: Evidence from Urbach-Wiethe disease

When presented in a neutral context, emotional items interfere with episodic encoding of temporally contiguous non-emotional items, resulting in dissociable valence-dependent retrograde and arousal-dependent anterograde modulatory effects. By studying two rare patients with congenital lipoid protein...

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Bibliographic Details
Published in:Neuropsychologia 2007-01, Vol.45 (5), p.877-884
Main Authors: Hurlemann, René, Wagner, Michael, Hawellek, Barbara, Reich, Harald, Pieperhoff, Peter, Amunts, Katrin, Oros-Peusquens, Ana-Maria, Shah, Nadim J., Maier, Wolfgang, Dolan, Raymond J.
Format: Article
Language:English
Subjects:
Adaptation, Psychological
Adult
Adult and adolescent clinical studies
Amnesia
Amygdala
Amygdala - pathology
Amygdala - physiopathology
Analysis of Variance
Arousal - physiology
Biological and medical sciences
Case-Control Studies
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Emotion
Emotions - physiology
Episodic memory
Female
Humans
Hypermnesia
Lesion
Lipoid Proteinosis of Urbach and Wiethe - pathology
Lipoid Proteinosis of Urbach and Wiethe - psychology
Magnetic Resonance Imaging
Medical sciences
Memory - physiology
Nervous system (semeiology, syndromes)
Neurology
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reference Values
Twins, Monozygotic
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Summary:When presented in a neutral context, emotional items interfere with episodic encoding of temporally contiguous non-emotional items, resulting in dissociable valence-dependent retrograde and arousal-dependent anterograde modulatory effects. By studying two rare patients with congenital lipoid proteinosis (Urbach-Wiethe) and a focal disease emphasis on the basolateral amygdala (BLA), we demonstrate that this bidirectional modification of episodic encoding by emotion depends on the integrity of the amygdala, as both retrograde and anterograde modulatory effects are absent. Our findings implicate the amygdala in a neural circuitry that orchestrates rapid retrograde and anterograde regulation of episodic memory access upon criteria of behavioral significance.
ISSN:0028-3932
1873-3514
DOI:10.1016/j.neuropsychologia.2006.08.027