The risk of disseminated Bacille Calmette-Guerin (BCG) disease in HIV-infected children

Abstract Objectives Bacille Calmette-Guerin (BCG), a live attenuated Mycobacterium bovis vaccine, poses a risk to human immunodeficiency virus (HIV)-infected children; this risk has not been well quantified. We estimate the risk of disseminated BCG disease in HIV-infected children in a setting highl...

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Bibliographic Details
Published in:Vaccine 2007-01, Vol.25 (1), p.14-18
Main Authors: Hesseling, Anneke C, Marais, Ben J, Gie, Robert P, Schaaf, H. Simon, Fine, Paul E.M, Godfrey-Faussett, Peter, Beyers, Nulda
Format: Article
Language:English
Subjects:
Adolescent
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - microbiology
Allergy and Immunology
Applied microbiology
Bacterial diseases
BCG
BCG Vaccine - administration & dosage
BCG Vaccine - adverse effects
Biological and medical sciences
Child
Child, Preschool
Children & youth
Disease transmission
Disseminated
Female
Fundamental and applied biological sciences. Psychology
HIV
HIV Infections - complications
HIV Infections - epidemiology
HIV Infections - immunology
Human bacterial diseases
Human immunodeficiency virus
Human viral diseases
Humans
Immunization
Incidence
Infant
Infant, Newborn
Infants
Infectious Disease Transmission, Vertical
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Mycobacterium bovis
Mycobacterium bovis - immunology
Mycobacterium bovis - pathogenicity
Public health
Risk Factors
South Africa - epidemiology
Tuberculosis
Tuberculosis - complications
Tuberculosis - epidemiology
Tuberculosis - microbiology
Tuberculosis - prevention & control
Tuberculosis and atypical mycobacterial infections
Vaccination - statistics & numerical data
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
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Summary:Abstract Objectives Bacille Calmette-Guerin (BCG), a live attenuated Mycobacterium bovis vaccine, poses a risk to human immunodeficiency virus (HIV)-infected children; this risk has not been well quantified. We estimate the risk of disseminated BCG disease in HIV-infected children in a setting highly endemic for tuberculosis and HIV. Design and methods We conducted a prospective hospital-based surveillance study in the Western Cape Province, South Africa. Clinical and laboratory-confirmed cases of disseminated BCG disease in children
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2006.07.020