IGF1, growth pathway polymorphisms and schizophrenia: A pooling study

It has been hypothesized that insulin‐like growth factors (IGFs) and components of the growth‐hormone (GH)‐IGF axis may underlie reported associations of poor fetal and childhood growth with schizophrenia. We have investigated the association of schizophrenia with 16 SNPs spanning the IGF1 gene with...

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Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-01, Vol.144B (1), p.117-120
Main Authors: Gunnell, D., Lewis, S., Wilkinson, J., Georgieva, L., Davey, G. Smith, Day, I.N.M., Holly, J.M.P., O'Donovan, M.C., Owen, M.J., Kirov, G., Zammit, S.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
Bulgaria
Case-Control Studies
DNA - genetics
Female
Human Growth Hormone - genetics
Humans
IGF1
Insulin Receptor Substrate Proteins
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Proteins - genetics
Insulin-Like Growth Factor I - genetics
Ireland
Linkage Disequilibrium
Male
Medical genetics
Medical sciences
Phosphoproteins - genetics
Polymorphism, Single Nucleotide
pooling study
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - genetics
United Kingdom
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Summary:It has been hypothesized that insulin‐like growth factors (IGFs) and components of the growth‐hormone (GH)‐IGF axis may underlie reported associations of poor fetal and childhood growth with schizophrenia. We have investigated the association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter‐marker distance of approximately 2–3 kb. We also examined associations with four common functional polymorphisms of genes involved in aspects of the GH‐IGF system—the IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), growth hormone (GH1), and IGF binding protein‐3 (IGFBP3). The study was based on an analysis of pooled DNA samples from 648 UK and Irish cases of schizophrenia and 712 blood donor controls and of 297 Bulgarian parent offspring trios. In replicated pool analyses, none of the 16 SNPs in IGF1 nor the 4 key SNPs in the other growth pathway genes were associated with schizophrenia. SNP coverage of IGF1 was extensive, so our findings do not support a major role for IGF‐I in the aetiology of schizophrenia. © 2006 Wiley‐Liss, Inc.
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30396