Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil

Self-nanoemulsifying drug delivery systems (SNEDDS) were developed with the objective to overcome problems associated with the delivery of cefpodoxime proxetil (CFP), a poorly bioavailable high dose antibiotic having pH dependant solubility. Solubility of CFP in oily phases and surfactants was deter...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2007-02, Vol.329 (1), p.166-172
Main Authors: Date, Abhijit A., Nagarsenker, M.S.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Biological and medical sciences
Cefpodoxime Proxetil
Ceftizoxime - administration & dosage
Ceftizoxime - analogs & derivatives
Drug Delivery Systems
Emulsions
General pharmacology
Hydrogen-Ion Concentration
Medical sciences
Nanomedicine
pH dependant solubility
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
SNEDDS
Solubility
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Self-nanoemulsifying drug delivery systems (SNEDDS) were developed with the objective to overcome problems associated with the delivery of cefpodoxime proxetil (CFP), a poorly bioavailable high dose antibiotic having pH dependant solubility. Solubility of CFP in oily phases and surfactants was determined to identify components of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify selected oily phases. Ternary phase diagrams were constructed to identify area of nanoemulsification for the selected systems. The influence of CFP and the pH of dilution medium on the phase behavior of selected system were assessed. The globule size of optimized CFP SNEDDS in various dissolution media was determined to check the effect of pH on its behavior. The optimized CFP SNEDDS needed surfactant content less than 40% and yielded nanoemulsion of mean globule size 170 nm, which was not affected by the pH of dilution medium. The optimized SNEDDS released CFP completely within 20 min irrespective of the pH of dissolution medium.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2006.08.038