Rett Syndrome and Plasma Leptin Levels

Objective To describe in patients with Rett syndrome (classic and preserved-speech variant) plasma leptin levels and their relationship to BMI (body mass index) and age. Study design Female patients (n = 48; age range 3–20 years) affected by classic Rett syndrome were enrolled into the study. Eleven...

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Bibliographic Details
Published in:The Journal of pediatrics 2007, Vol.150 (1), p.37-39
Main Authors: Blardi, P., MD, de Lalla, A., PhD, D’Ambrogio, T., MD, Zappella, M., MD, Cevenini, G., PhD, Ceccatelli, L., Biol D, Auteri, A., MD, Hayek, J., MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Biological and medical sciences
Biomarkers - blood
Body Mass Index
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
General aspects
Humans
Italy - epidemiology
Leptin - blood
Medical sciences
Pediatrics
Prevalence
Rett Syndrome - blood
Rett Syndrome - epidemiology
Risk Factors
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Summary:Objective To describe in patients with Rett syndrome (classic and preserved-speech variant) plasma leptin levels and their relationship to BMI (body mass index) and age. Study design Female patients (n = 48; age range 3–20 years) affected by classic Rett syndrome were enrolled into the study. Eleven female patients, age range 3 to 20 years, with preserved-speech variant Rett syndrome were included in the study. Controls were 24 healthy female subjects, age range 3 to 20 years. Blood samples (3 mL) were withdrawn from an antecubital vein in the morning; plasma leptin concentrations were detected by enzyme-linked immunosorbent assay method. Results Patients with classic Rett syndrome and preserved-speech variant had leptin values significantly higher than controls. Leptin concentrations did not significantly differ between patients with classic Rett and preserved-speech variant. Leptin values positively correlated with age and BMI. Conclusions Because in all patients the increased leptin concentrations were not associated to obesity, we hypothesize that in patients with Rett syndrome leptin might participate to clinical manifestations other than weight balance.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2006.10.061