Prognostic value of the apoptosis related genes BCL2 and BCL2L12 in breast cancer

Abstract Many members of BCL2 ( Bcl -2) apoptosis-related genes were found to be differentially expressed in various malignancies and were proposed as prognostic cancer biomarkers. Recently, a new member of the BCL2 gene family, BCL2L12 , was cloned and was found to be expressed in mammary gland. In...

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Bibliographic Details
Published in:Cancer letters 2007-03, Vol.247 (1), p.48-55
Main Authors: Thomadaki, Hellinida, Talieri, Maroulio, Scorilas, Andreas
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Amino acids
Apoptosis
Bcl-2 gene family
BCL2
BCL2L12
Biomarkers
Breast cancer
Breast Neoplasms - genetics
Colon
Colorectal cancer
Female
Gene expression
Gene Expression Regulation, Neoplastic
Genes, bcl-2
Hematology, Oncology and Palliative Medicine
Histology
Humans
Medical prognosis
Medical research
Middle Aged
Muscle Proteins - genetics
Prognosis
Prognostic markers
Proto-Oncogene Proteins c-bcl-2 - genetics
RNA, Messenger - analysis
Survival Analysis
Time Factors
Womens health
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Summary:Abstract Many members of BCL2 ( Bcl -2) apoptosis-related genes were found to be differentially expressed in various malignancies and were proposed as prognostic cancer biomarkers. Recently, a new member of the BCL2 gene family, BCL2L12 , was cloned and was found to be expressed in mammary gland. In the present study, 55 specimens from patients with, histologically confirmed, epithelial breast carcinoma were analyzed for BCL2 and BCL2L12 gene expression by RT-PCR. Increased expression of BCL2 gene was found in patients belonging to the age groups 55 years, as well as in estrogen receptors (ER)-positive patients and in BCL2L12 -positive tumors. In addition, BCL2 or BCL2L12 -positive patients were found to be almost four times less likely to relapse or die in comparison to BCL2 or BCL2L12 -negative patients, respectively. Multivariate analysis revealed that BCL2 and BCL2L12 might be used as independent prognostic biomarkers in breast cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2006.03.016