Clinicopathologic and prognostic significance of matrix metalloproteinases in rectal cancer

The aim of this study was to determine the prognostic role of matrix metalloproteinases in rectal cancer. Formalin-fixed and paraffin-embedded tissue sections of 94 rectal carcinomas were used for the immunohistochemical analysis of matrix metalloproteinases (MMP)-2, MMP-7, MT1-MMP, and tissue inhib...

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Bibliographic Details
Published in:International journal of colorectal disease 2007-02, Vol.22 (2), p.127-136
Main Authors: SCHWANDNER, O, SCHLAMP, A, BROIL, R, BRUCH, H. P
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Male
Matrix Metalloproteinase 14 - analysis
Matrix Metalloproteinase 14 - biosynthesis
Matrix Metalloproteinase 2 - analysis
Matrix Metalloproteinase 2 - biosynthesis
Matrix Metalloproteinase 7 - analysis
Matrix Metalloproteinase 7 - biosynthesis
Medical sciences
Middle Aged
Predictive Value of Tests
Rectal Neoplasms - chemistry
Rectal Neoplasms - metabolism
Rectal Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Tissue Inhibitor of Metalloproteinase-2 - analysis
Tissue Inhibitor of Metalloproteinase-2 - biosynthesis
Tumors
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Summary:The aim of this study was to determine the prognostic role of matrix metalloproteinases in rectal cancer. Formalin-fixed and paraffin-embedded tissue sections of 94 rectal carcinomas were used for the immunohistochemical analysis of matrix metalloproteinases (MMP)-2, MMP-7, MT1-MMP, and tissue inhibitor of metalloproteinases (TIMP)-2. Inclusion criteria were sporadic rectal adenocarcinoma resected curatively (including total mesorectal excision), adjuvant radiochemotherapy in UICC stages II and III, and complete intra-institutional follow-up. Results of immunohistochemistry were correlated with clinical and histopathologic data from the prospective rectal cancer registry and prognosis. End points of the prognostic analysis were tumor progression caused by local and/or distant recurrence and 5-year survival (disease-free and overall). To assess prognostic significance, statistics included univariate and multivariate analysis (p
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-006-0173-y