What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? A review and update

Summary Numerous immunohistochemical markers that can assist in the diagnosis of epithelioid mesotheliomas, some of which have only recently been recognized, are currently available. Because the various types of carcinomas express these markers differently, their selection for inclusion in a diagnos...

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Bibliographic Details
Published in:Human pathology 2007, Vol.38 (1), p.1-16
Main Author: ORDONEZ, Nelson G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - analysis
Calbindin 2
Carcinoma
Cell adhesion & migration
Diagnosis, Differential
Epithelioid Cells - chemistry
Epithelioid Cells - pathology
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Keratin-5 - analysis
Keratin-6 - analysis
Medical sciences
Membrane Glycoproteins - analysis
Mesothelioma
Mesothelioma - metabolism
Mesothelioma - pathology
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Proteins
S100 Calcium Binding Protein G - analysis
Tumors
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Summary:Summary Numerous immunohistochemical markers that can assist in the diagnosis of epithelioid mesotheliomas, some of which have only recently been recognized, are currently available. Because the various types of carcinomas express these markers differently, their selection for inclusion in a diagnostic panel can vary according to the differential diagnosis. This article provides a critical review of all of the information that is presently available on those markers that are believed to have the greatest potential for assisting in distinguishing between epithelioid mesotheliomas and those carcinomas with which they are most likely to be confused. Information is also provided regarding the panels of immunohistochemical markers that are, at present, recommended in these differential diagnoses.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2006.08.010