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What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? A review and update
Summary Numerous immunohistochemical markers that can assist in the diagnosis of epithelioid mesotheliomas, some of which have only recently been recognized, are currently available. Because the various types of carcinomas express these markers differently, their selection for inclusion in a diagnos...
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| Published in: | Human pathology 2007, Vol.38 (1), p.1-16 |
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| container_title | Human pathology |
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| creator | ORDONEZ, Nelson G |
| description | Summary Numerous immunohistochemical markers that can assist in the diagnosis of epithelioid mesotheliomas, some of which have only recently been recognized, are currently available. Because the various types of carcinomas express these markers differently, their selection for inclusion in a diagnostic panel can vary according to the differential diagnosis. This article provides a critical review of all of the information that is presently available on those markers that are believed to have the greatest potential for assisting in distinguishing between epithelioid mesotheliomas and those carcinomas with which they are most likely to be confused. Information is also provided regarding the panels of immunohistochemical markers that are, at present, recommended in these differential diagnoses. |
| doi_str_mv | 10.1016/j.humpath.2006.08.010 |
| format | article |
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Information is also provided regarding the panels of immunohistochemical markers that are, at present, recommended in these differential diagnoses.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Calbindin 2</subject><subject>Carcinoma</subject><subject>Cell adhesion & migration</subject><subject>Diagnosis, Differential</subject><subject>Epithelioid Cells - chemistry</subject><subject>Epithelioid Cells - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Keratin-5 - analysis</subject><subject>Keratin-6 - analysis</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - analysis</subject><subject>Mesothelioma</subject><subject>Mesothelioma - metabolism</subject><subject>Mesothelioma - pathology</subject><subject>Pathology</subject><subject>Pathology. Cytology. 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A review and update</title><author>ORDONEZ, Nelson G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-5b0e278b2cd6530b40a07b54fce0608041a3d16581695c7c266511f49d834dcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Calbindin 2</topic><topic>Carcinoma</topic><topic>Cell adhesion & migration</topic><topic>Diagnosis, Differential</topic><topic>Epithelioid Cells - chemistry</topic><topic>Epithelioid Cells - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Keratin-5 - analysis</topic><topic>Keratin-6 - analysis</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - analysis</topic><topic>Mesothelioma</topic><topic>Mesothelioma - metabolism</topic><topic>Mesothelioma - pathology</topic><topic>Pathology</topic><topic>Pathology. 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Miscellaneous investigative techniques</topic><topic>Proteins</topic><topic>S100 Calcium Binding Protein G - analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ORDONEZ, Nelson G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ORDONEZ, Nelson G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? A review and update</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2007</date><risdate>2007</risdate><volume>38</volume><issue>1</issue><spage>1</spage><epage>16</epage><pages>1-16</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Numerous immunohistochemical markers that can assist in the diagnosis of epithelioid mesotheliomas, some of which have only recently been recognized, are currently available. Because the various types of carcinomas express these markers differently, their selection for inclusion in a diagnostic panel can vary according to the differential diagnosis. This article provides a critical review of all of the information that is presently available on those markers that are believed to have the greatest potential for assisting in distinguishing between epithelioid mesotheliomas and those carcinomas with which they are most likely to be confused. 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| ispartof | Human pathology, 2007, Vol.38 (1), p.1-16 |
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| source | ScienceDirect Journals |
| subjects | Biological and medical sciences Biomarkers, Tumor - analysis Calbindin 2 Carcinoma Cell adhesion & migration Diagnosis, Differential Epithelioid Cells - chemistry Epithelioid Cells - pathology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Keratin-5 - analysis Keratin-6 - analysis Medical sciences Membrane Glycoproteins - analysis Mesothelioma Mesothelioma - metabolism Mesothelioma - pathology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proteins S100 Calcium Binding Protein G - analysis Tumors |
| title | What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? A review and update |
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