Iridium-Catalyzed Conversion of Alcohols into Amides via Oximes

The iridium catalyst [Ir(Cp*)Cl2]2 is effective for the rearrangement of oximes to furnish amides. The reaction has been combined with catalytic transfer hydrogenation between an alcohol and alkene to allow the conversion of alcohols into amides in a one-pot process.

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Bibliographic Details
Published in:Organic letters 2007-01, Vol.9 (1), p.73-75
Main Authors: Owston, Nathan A, Parker, Alexandra J, Williams, Jonathan M. J
Format: Article
Language:English
Subjects:
Alcohols - chemistry
Amides - chemistry
Catalysis
Iridium - chemistry
Molecular Structure
Oxidation-Reduction
Oximes - chemistry
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Description
Summary:The iridium catalyst [Ir(Cp*)Cl2]2 is effective for the rearrangement of oximes to furnish amides. The reaction has been combined with catalytic transfer hydrogenation between an alcohol and alkene to allow the conversion of alcohols into amides in a one-pot process.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol062549u